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In the 1920s, orphan Jo Laurence grows up as a 'medicine runner' in Kona, Hawaii. Love and racism play a role in his forbidden love for Grace.
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In the 1920s Hawaii, orphan boy Jo Laurence grows up under the care of a doctor as a 'medicine runner'. He slowly finds his place despite the racism around him. Jo falls in love with Grace, but her father wants to marry her off to Dr. Reyes. After Dr. Reyes's true nature comes to light and Doc dies while helping, Jo must decide how far he is willing to go for love and justice.